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帮助科研人员筛选研究问题、评估项目风险并制定科研策略
复制安装指令，让 AI 自动完成配置 · 推荐新手
请帮我安装 askskill 上的 "scientific-problem-selection" 技能： 1. 下载 https://raw.githubusercontent.com/anthropics/knowledge-work-plugins/main/bio-research/skills/scientific-problem-selection/SKILL.md 2. 保存为 ~/.claude/skills/scientific-problem-selection/SKILL.md 3. 装好后重载技能，告诉我可以用了
我在单细胞测序和空间转录组两个方向之间犹豫。请根据创新性、可行性、所需资源、发表潜力和我的背景，帮我比较并建议我下一步应优先做什么。
给出结构化对比、关键判断依据、主要风险与明确的方向建议。
我的研究项目已经卡住两个月：实验结果不稳定，假设也不再清晰。请帮我诊断可能的问题来源，列出可验证的假设，并给出一个两周内可执行的排障计划。
输出问题诊断框架、优先级排序的排查路径，以及短期行动计划。
我有一个新课题想法，想研究某种药物对衰老相关通路的影响。请像导师一样帮我评估它的科学价值、可操作性、潜在陷阱、最低可行研究设计，并建议是否值得投入半年时间。
提供课题价值判断、风险评估、最小可行方案及是否推进的建议。
A conversational framework for systematic scientific problem selection based on Fischbach & Walsh's "Problem choice and decision trees in science and engineering" (Cell, 2024).
Present users with three entry points:
1) Pitch an idea for a new project — to work it up together
2) Share a problem in a current project — to troubleshoot together
3) Ask a strategic question — to navigate the decision tree together
This conversational entry meets scientists where they are and establishes a collaborative tone.
Ask: "Tell me the short version of your idea (1-2 sentences)."
After the user shares their idea, return a quick summary (no more than one paragraph) demonstrating understanding. Note the general area of research and rephrase the idea in a way that highlights its kernel—showing alignment and readiness to dive into details.
Then ask for more detail: "Now give me a bit more detail. You might include, however briefly or even say where you are unsure:
From there, guide the user through the early stages of problem selection and evaluation:
See references/01-intuition-pumps.md, references/02-risk-assessment.md, references/03-optimization-function.md, and references/04-parameter-strategy.md for detailed guidance.
Ask: "Tell me a short version of your problem (1-2 sentences or whatever is easy)."
After the user shares their problem, return a quick summary (no more than one paragraph) demonstrating understanding. Note the context of the project where the problem occurred and rephrase the problem—highlighting its core essence—so the user knows the situation is understood. Also raise additional questions that seem important to discuss.
Then ask: "Now give me a bit more detail. You might include, however briefly:
From there, guide the user through troubleshooting and decision tree navigation:
Always include workarounds that might be useful whether or not the problem can be fixed easily.
See references/05-decision-tree.md, references/06-adversity-planning.md, references/07-problem-inversion.md, and references/04-parameter-strategy.md for detailed guidance.
Ask: "Tell me the short version of your question (1-2 sentences)."
After the user shares their question, return a quick summary (no more than one paragraph) demonstrating understanding. Note the broader context and rephrase the question—highlighting its crux—to confirm alignment with their thinking.
Then ask: "Now give me a bit more detail. You might include, however briefly:
…
围绕客户问题进行多来源调研与溯源，快速整理背景并支持准确回复。
通过苏格拉底式提问引导用户自主发现思路、答案与改进方向。